Duloxetine: urinary incontinence and marketing authorization incontinence

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Around 1.5% of adults in Europe and the USA have urge urinary incontinence (involuntary leakage immediately preceded or accompanied by urgency) (Abrams 2003; Irwin 2006). This is usually due to overactive bladder syndrome (defined as urgency, with or without urge incontinence, and usually with frequency and nocturia) (Abrams 2003). The symptoms of an overactive bladder are thought to be due to ...

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This manuscript reviews the pharmacodynamics and pharmacokinetics of duloxetine and its efficacy and safety in women with stress urinary incontinence. Duloxetine is a selective inhibitor of neuronal serotonin and norepinephrine uptake which increases urethral striated muscle activity and bladder capacity. Duloxetine is readily absorbed and extensively metabolized; cytochrome P450 1A2 (CYP1A2) i...

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Update on duloxetine for the management of stress urinary incontinence

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ژورنال

عنوان ژورنال: Canadian Medical Association Journal

سال: 2017

ISSN: 0820-3946,1488-2329

DOI: 10.1503/cmaj.732561